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To explore the structure of in vitro-modified HIV-1 long terminal repeats, ¹⁹F nuclear magnetic resonance was applied in this investigation. 5-fluoro-2′-deoxyuridine (FdU) and 5-fluorobenzofuran-2′-deoxyuridine (FBFdU), acting as hairpin structures and G-quadruplex sensors, exhibit unique spectroscopic signatures toward different G-quadruplex topologies formed by LTR guanine-rich oligonucleotides [35, 36]. Researchers employed ¹⁹F NMR techniques with environment-sensitive FdU and FBFdU to elucidate the cellular environment structures of G-quadruplets within the HIV-1 LTR and monitor interactions between G-quadruplets and hairpin-specific ligands.帮我配一个图，biorender风格，要发表期刊