

Scientific mechanism diagram, BioRender style, flat vector illustration. Focus on the TRIP12-ARF-p53 signaling axis. Core interaction: A large icon of TRIP12 (HECT E3 ligase) with a “Loss of Function” (LoF) symbol. A red dashed inhibition line from TRIP12 to ARF is broken. ARF protein icons are shown in high density, inhibiting MDM2 (E3 ligase). Consequently, p53 protein is depicted as high concentration and glowing. p53 binds to DNA promoters of p21 and BAX, triggering neuronal apoptosis. The background includes a simplified cell structure (cytoplasm and nucleus). Professional palette: muted blues, reds, and greens. No labels or text, use intuitive symbols (arrows and T-bars). High contrast, professional scientific aesthetic.
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