

A professional BioRender-style medical graphic explaining the “Mirror Phenotype” of TRIP12. The flow moves from top to bottom. Top: A graphic representation of the “Intragenic Duplication (Exon 9-10)” within the TRIP12 gene. Middle: The molecular consequence: TRIP12 LoF → ARF accumulation → p53 hyperactivation. Bottom: The physiological outcome: a detailed icon of a developing brain showing “Neuronal Depletion” and shrinking to a “Microcephaly” phenotype. Use high-quality vector icons for proteins and cell components. Color scheme: Green arrows for the pathological cascade, red T-bars for inhibition. Clear white background, minimalist and professional layout, sharp edges, 4k resolution.
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