简约风医学科研机制示意图插画素材

Scientific diagram showing the complete mechano-topological-signal synergy system for LES regeneration. Central: endoscopic injection of MSC-laden SilkMA/GelMA hydrogel with rod-shaped sacrificial templates into gastroesophageal junction. Surrounding four quadrants: (1) Stiffness-mediated YAP/TAZ mechanotransduction (15-30 kPa optimal window), (2) Peristalsis-driven template alignment forming circular pores, (3) MA-Heparin controlled release of VEGF and TGF-β1/BMP4, (4) Hierarchical vascularization preventing necrotic core. Temporal flow from injection to functional bio-sphincter formation. Nature Biomedical Engineering style, vector art, clinical blue-teal palette with gold accents, high detail, 8k resolution.