

Following spinal cord injury, microglia undergo immunometabolic rewiring via the CD74-mTOR signaling axis, characterized by reduced oxidative phosphorylation (pro-repair) and enhanced glycolysis/pentose phosphate pathway (neurotoxic). This immunometabolic rewiring leads to increased release of neurotoxic factors, diminished synaptic clearance, and disruption of protective functional coupling with neurons. Illustration style: clean and visually appealing, designed with reference to BioRender and Cell styles.
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