

Following spinal cord injury, microglia undergo immunometabolic rewiring via the CD74‑mTOR signaling axis, shifting from an "OXPHOS‑repair phenotype" to a "glycolysis/pentose phosphate pathway‑neurotoxic phenotype." This leads to enhanced neurotoxic inflammation, impaired phagocytic clearance, and disruption of the protective microglia‑neuron functional coupling. Requirements: concise and aesthetically pleasing, designed with reference to the styles of BioRender and Cell.
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