

Figure 1: The Immunopharmacological Network of CB2 in Atopic Dermatitis绘图指令 (Prompt for BioRender / Designer): Layout: Divide the image into three sections: Epidermis (top), Dermis (middle), Nerve/Ganglion (bottom). Section 1 (Epidermis): Draw damaged Keratinocytes. Show CB2 Agonist (drug) binding to receptors. Result: ↑ ↑ Filaggrin (Barrier repair), ↓ ↓ TSLP (Stop the trigger). Section 2 (Dermis - Immune): Draw a Th2 Cell. Show CB2 binding → → ↓ ↓ GATA3 → → ↓ ↓ IL-4/IL-13. Draw a Mast Cell. Show CB2 binding → → ↓ ↓ Ca2+ influx → → No Histamine release. Section 3 (Nerves - Pruritus): Draw a sensory nerve ending. Show CB2 binding → → inhibition of TRPV1 channel → → “STOP” sign on itch signal transmission. Style: Clean, scientific schematic. Use distinct colors for inhibition (red flat-head arrows) and activation (green arrows).
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