

Figure 1: Molecular Mechanisms of CB2 Signaling in AD (该图应展示CB2受体在不同细胞上的作用) 绘图指令 (Prompt for BioRender/Illustrator): Central Layout: Cross-section of inflamed skin showing Keratinocytes (top), Nerve ending (middle), and Dermis with T-cells/Mast cells (bottom). Keratinocytes: Show CB2 activation → → ↓ ↓ TSLP, ↓ ↓ IL-33, ↑ ↑ Filaggrin. T Cells (Th2): Show CB2 → → ↓ ↓ STAT6 → → ↓ ↓ IL-4, IL-13 release. Sensory Nerve: Show CB2 → → Inhibition of TRP channels → → ↓ ↓ Itch signal (Pruritus). Mast Cell: Show CB2 → → ↓ ↓ Histamine release. Style: Professional, 2D vector style, colors: Blue (CB2 agonist), Red (Inflammatory cytokines), Green (Therapeutic effect).
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