

Style: Flat vector illustration, BioRender-inspired, minimalist scientific diagram, no 3D, no photorealism, clean lines, Nature Cell Biology editorial aesthetic, white background, professional color palette (blues, teals, corals, grays) Layout: Horizontal tri-panel flow diagram (left→center→right) with central mechanism inset Panel 1 - Model Establishment (Left): Eight female Lewis rats (4-week-old) per group, simplified icon style Three experimental arms stacked vertically with connecting arrows: • Control: Single rat icon + water bottle labeled "50 μg/L Iodine" • AIT (Tg+HI): Rat icon + syringe with "pTg-CFA" (3 cycles, 2-week intervals) + water bottle "200 mg/L Iodine" • DEC (Tg+HI+DEC): Same as AIT + syringe labeled "DEC 1 mg/kg" at Week 10 Timeline bar below: Week 0 (immunization) → Week 10 (DEC treatment, 7 days) → Week 12 (euthanasia) Small blood drop icon indicating serum collection
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