

Style: Modern minimalist BioRender icon design.Layout: 3-tier pyramid with upward connecting arrows.Color: Deep blue → teal → bright yellow gradient.Tier1 (Base) Title: Contribution1: Elucidating Cell Fate Core Mechanism Visuals: Central ER (ERS as Hub); PI3K/Akt/mTOR (PI3K inhibitor-blocked) & VEGF (Endostatin-blocked) with Synergistic Induction arrows to ER; ER links to balance scale: protective autophagy vs apoptosis+lethal autophagy, bold arrow tilting to apoptosis/lethal autophagy.Tier2 (Middle) Title: Contribution2: TNBC Potent Combination Strategy Visuals: Endostatin + PI3K Inhibitor (Synergy, CI<1); thick arrow to shrinking tumor spheroid/volume graph; 3 subtype cancer cells (Basal-like, LAR, TNCL), combination arrow acting on all.Tier3 (Top) Title: Contribution3: Promoting Bench-to-Bedside Translation Visuals: Patient silhouette; arrow to tissue slide/DNA-protein; clinical trial flask (Future Trial Foundation); survival curve, combination group with longer survival.
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