

Style: Clean, flat, icon-based (BioRender standard).Colors: Panel A (Status): Calm blue/gray; Panel B (Challenges): Warning red/orange/dark purple.Layout: Left-Right Split (A left, B right).Panel A: Epidemiology & Triple-Negative TraitsStats: Women silhouettes (highlight breast) + bubbles: Most Common in Women, <40y Trend, TNBC:15-20%, 5-yr Mortality ~40%.Cell Traits: Breast cancer cell; ER/PR/HER2 receptors (red "X"), note: Targeted Therapy Inapplicable.Current Tx: IV bag (Chemotherapy) → cancer cell (only systemic Tx).Panel B: Therapeutic DilemmasArrows from chemo icon to 3 challenges:Toxicity: Neuron/bone marrow cells (red damage); Neurotoxicity/Myelosuppression → Intolerance.Heterogeneity: Tumor with 3 subtypes (Basal-like/LAR/TNCL); chemo kills 1 type; Hard to Treat All.Pathway Hyperactivation: PI3K/Akt/mTOR pathway (glowing §); → Resistance/Proliferation/Metastasis.
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