

Style: Clean, modern, BioRender standard icons. Panel 1: Current Care • Figure: Large TNBC cell; ER/PR/HER2 with red "X" (absent/non-functional). • Treatment: Top-left chemo IV bag; arrows direct molecules to the cell. • Outcome: Mild blebbing + apoptosis icon (partial effect); cell intact. Text: *Limited Efficacy & High Recurrence Rate*. Panel 2: Key Challenges 4 subsections (arrows from surviving TNBC cell): 1. Toxicity: Chemo harms neurons/marrow (distress icons). Label: 1. Off-Target Toxicity. 2. Resistance: i. ABC Transporter ejects chemo; ii. PI3K/Akt/mTOR bypasses inhibitor. 3. Heterogeneity: 3 varied TNBC cells; chemo kills one, spares two. Label: 3. Tumor Heterogeneity. 4. Immune Escape: PI3K/Akt-VEGF crosstalk; TAMs/MDSCs shield from T-cells. Label: 4. Pathway Crosstalk.
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