

Scene Composition: A high-magnification view centered on the Soma of a postsynaptic neuron, surrounded by a PV Interneuron axon terminal, an Astrocyte, and an Activated Microglia. 1. The Hyperactive PV Neuron (Trigger): “Presynaptic axon terminal of a Parvalbumin (PV) interneuron (blue), firing intensely (lightning bolt icon). Releasing a high concentration of GABA neurotransmitters (yellow dots) into the synaptic cleft and extrasynaptic space.” Labels: “Hyperactive PV Interneuron”, “Excessive GABA Release”. 2. The Astrocyte Response (The Mediator): “An Astrocyte (green) process adjacent to the synapse. GABA molecules binding to astrocyte surface receptors. Inside the astrocyte, show a signaling pathway arrow: ‘GABA → → β β-arrestin pathway’. Astrocyte secreting C3 complement proteins (red Y-shaped or globular icons) rapidly.” Labels: “Astrocyte”, “C3 Generation”, “GABA/ β β-arrestin pathway”.
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