手绘风细胞结构DNA科研插画素材

Scientific illustration in BioRender style depicting the multimodal mechanism of action of anticancer Ruthenium complexes. Central Composition: A large cross-section of a cancer cell showing nucleus, mitochondria, ER, and cell membrane. 1. Nucleus (Right): DNA double helix interacting with Ruthenium complexes via groove binding (intercalation), covalent binding to Guanine N7, and electrostatic attraction. Show DNA unwinding and bending. Include inhibition of DNMT1 at CpG islands causing gene re-expression. Show inhibition of HDACs causing histone hyperacetylation. Depict DNA damage activating ATM-Chk2 leading to G2/M arrest. 2. Mitochondria (Left): Swollen mitochondria with disrupted cristae. Ruthenium accumulation driven by membrane potential. Inhibition of Complex I and ANT protein. Release of ROS and depletion of Glutathione. Opening of mPTP pore leading to apoptosis.