

Layout: Two-panel comparison (Top: TKI alone; Bottom: TKI + SBRT). Panel 1 (Standard): Image: Human silhouette with lung primary tumor and brain/bone metastases (purple clusters). Action: Blue pill icons (3rd-gen TKI) targeting EGFR receptors on cell surface. Result: Tumors shrink but remain visible; blood vessel contains red DNA fragments (ctDNA+ / MRD persistence). Label: “Partial Response & Relapse”. Panel 2 (Proposed): Action: Same TKI pills PLUS gold radiation beams (SBRT) precisely striking all macro-lesions (Lung/Brain/Bone). Cellular Zoom-in: SBRT causing DNA double-strand breaks; TKI blocking survival signaling. Result: Tumors replaced by small grey scars. Blood vessel is empty of ctDNA (MRD clearance). Final Output: Large green checkmark. Label: “FUNCTIONAL CURE”. Criteria Box: 1. Imaging NED; 2. ctDNA Negative; 3. Long-term Treatment-free Survival. Style: Clean, professional, scientific.
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